Cumulative exposures to glycaemia and lipids are associated with coronary artery disease in type 1 diabetes: a call for action
Authors' conclusion
Both hyperglycaemia and dyslipidaemia are independently associated with CAD in type 1 diabetes. These findings emphasize the importance of reaching an HbA1c below 53 mmol/mol (7%) and minimizing lipid exposure, as well as calling on health care professionals to not settle for suboptimal care, but to continue their support and encouragement towards better management of diabetes.
Study context
- Population
- Adults with T1D from the FinnDiane cohort, without end-stage kidney disease and no history of coronary artery disease (CAD) or stroke at baseline
- Participants
- 3,495 adults
- Exposure
- Cumulative glycaemic and lipid exposure and incident CAD
- Outcome
- First-ever CAD event
- Follow-up
- Median 19.38 years
Main finding
As reported in the abstract
Incident CAD
Participants with first-ever CAD event
534
CGEhg (cumulative hyperglycaemic exposure, time above HbA1c 53 mmol/mol [7%]), OR for incident CAD
1.03
95% CI 1.02–1.05p < 0.001
Observational data: associations, not effects.
Original publication
Cumulative exposures to glycaemia and lipids are associated with coronary artery disease in type 1 diabetes: a call for action. Cardiovasc Diabetol. Published 13 June 2025. doi:10.
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