Lipids & metabolic liver disease
Correlative association between FIB-4 index and graded coronary artery disease severity among MASLD patients: A hypertension-stratified analysis
Authors' conclusion
For clinical cardiovascular risk stratification purposes, FIB-4 showed an independent statistical association with CAD severity in MASLD, with a within-subgroup significant association observed among hypertensive patients, although formal interaction testing did not confirm statistically meaningful effect modification (all P for interaction > 0.05).
Study context
- Population
- Patients presenting with chest pain with MASLD who underwent coronary angiography
- Participants
- 423 patients
- Exposure
- FIB-4 index vs coronary artery disease (CAD) severity
- Outcome
- CAD severity graded into 4 ordinal groups by Gensini score
Methodological detailshypertension-stratified analysis, multivariable ordinal logistic regression, Bootstrap validation
- Hypertension-stratified analysis
- Multivariable ordinal logistic regression
- Bootstrap validation
Main finding
As reported in the abstract
Association of FIB-4 with CAD severity, by subgroup (fully adjusted)
Hypertensive patients: OR (P = 0.022)
1.507
Observational data: associations, not effects.
Further findings
FIB-4 and CAD severity, overall (adjusted for age, hypertension, diabetes history)
- OR (P = 0.016)
- 1.445
AUC of FIB-4 for moderate-to-severe CAD
- AUC
- 0.569
Original publication
Correlative association between FIB-4 index and graded coronary artery disease severity among MASLD patients: A hypertension-stratified analysis. Diabetes Res Clin Pract. Published 25 August 2026. doi:10.
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