Correlation of Histopathologic Subtypes of Primary Aldosteronism with Clinical Phenotypes and Postsurgical Outcomes
Authors' conclusion
The solitary group, followed by the mixed group, was associated with more severe hyperaldosteronism and more suppressed aldosterone production from the contralateral side than the nonclassical group. Histopathologic phenotypes were related to the clinical manifestations and may suggest postoperative prognosis.
Study context
- Population
- Patients consecutively operated for unilateral primary aldosteronism (PA), 2010–2020, 3 tertiary hospitals in South Korea
- Participants
- 240 participants
- Exposure
- Histopathologic subtypes of unilateral PA: solitary vs mixed vs nonclassical
- Solitaryn = 124
- Mixedn = 86
- Nonclassicaln = 30reference
- Outcome
- Plasma aldosterone concentration after saline loading
Methodological detailsmulticentre, consecutive patients, CYP11B2 immunostaining
- Multicentre
- Consecutive patients
- CYP11B2 immunostaining
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Baseline serum potassium
- Lower in solitary than mixed or nonclassical
Lateralization and contralateral indices
- Solitary and mixed had higher lateralization indices and lower contralateral indices than nonclassical
- Contralateral index lower in solitary than mixed
Antihypertensive medications after adrenalectomy · 6 to 12 months after adrenalectomy
- Fewer antihypertensive medications required for solitary and mixed than nonclassical
Original publication
Correlation of Histopathologic Subtypes of Primary Aldosteronism with Clinical Phenotypes and Postsurgical Outcomes. J Clin Endocrinol Metab. Published 21 December 2023. doi:10.
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