Association of Dip in Estimated Glomerular Filtration Rate (eGFR) With Clinical Outcomes in Unilateral Primary Aldosteronism Patients After Adrenalectomy
Authors' conclusion
Within 5 years post adrenalectomy, 17.3% of patients had reduced kidney function. Notably, individuals with an eGFR dip ratio worse than -30% faced higher MAKE risks, underscoring the need to monitor kidney function in PA patients after surgery.
Study context
- Population
- Patients with unilateral primary aldosteronism (PA) (unilateral PA (uPA)) who underwent adrenalectomy; divided into 4 groups by eGFR dip ratio
- Participants
- 445 patients
- Exposure
- eGFR dip ratio worse than −30% vs other eGFR dip groups
- eGFR dip worse than −30%n = 74
- Outcome
- Outcomes by eGFR dip ratio
- Follow-up
- 5.0 ± 3.6 years
Methodological detailsmulticenter, population-based
- Multicenter
- Population-based
Main finding
As reported in the abstract
Died (whole cohort)
2.9%
Cardiovascular composite events (whole cohort)
14.6%
Major adverse kidney events (MAKEs) (whole cohort)
17.3%
Observational data: associations, not effects.
Further findings
Factors associated with eGFR dip ratio worse than −30% (multivariate analysis)
- Older age, OR
- 1.04
- Preoperative eGFR, OR
- 1.02
- Hypokalemia, OR
- 0.45
- Preoperative systolic blood pressure, OR
- 1.03
- Plasma aldosterone concentration, OR
- 0.99
Baseline characteristics of eGFR dip worse than −30%
- Share of cohort with eGFR dip worse than −30%
- 16.6%
- Older, higher blood pressure, higher aldosterone concentration and lower serum potassium
Original publication
Association of Dip in eGFR With Clinical Outcomes in Unilateral Primary Aldosteronism Patients After Adrenalectomy. J Clin Endocrinol Metab. Published 5 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →