Correlation Between the Glycemia Risk Index and Longitudinal Hemoglobin A1c in Children and Young Adults With Type 1 Diabetes
Authors' conclusion
In youth with T1D, the GRI may be useful for evaluating quality of glycemia between scheduled clinic visits. Additional CGM-derived metrics are needed to quantify risk for hypoglycemia in this population.
Study context
- Population
- Youth with T1D (duration ≥1 year; ≥50% continuous glucose monitor (CGM) wear time), Midwest pediatric diabetes clinic network, March 2016 to May 2022; aged 2.5–18.0 years (median 13.4; IQR 5.2), 50.5% male
- Participants
- 719 participants
- Outcome
- Correlation between baseline GRI and longitudinal HbA1c
- Follow-up
- Baseline and 3, 6, 9 and 12 months
Methodological detailselectronic health records and CGM data, pediatric diabetes clinic network
- Electronic health records and CGM data
- Pediatric diabetes clinic network
Main finding
As reported in the abstract
Correlation of baseline GRI with HbA1c · baseline, 3, 6, 9 and 12 months
- R at baseline
- 0.68
- R at 3 months
- 0.65
- R at 6 months
- 0.60
- R at 9 months
- 0.57
- R at 12 months
- 0.52
Observational data: associations, not effects.
Further findings
Correlation of hemoglobin A1c (HbA1c) with glycemia risk index (GRI) high component (time in hyperglycemia) · all time points
- Strong positive correlations between HbA1c and time in hyperglycemia
Correlation of HbA1c with GRI low component (time in hypoglycemia) · all time points
- Substantially weaker, negative correlations between HbA1c and time in hypoglycemia
Original publication
Correlation Between the Glycemia Risk Index and Longitudinal Hemoglobin A1c in Children and Young Adults With Type 1 Diabetes. J Diabetes Sci Technol. Published 7 May 2024. doi:10.
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