Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes
Authors' conclusion
No significant common T2D and CAD susceptibility genetic association was demonstrated indicating distinct disease pathways. However, CAD patients carrying the T2D susceptibility gene TCF7L2 remain at higher risk for developing T2D emphasizing the need for frequent monitoring in this subgroup.
Study context
- Population
- Patients with coronary artery disease (CAD)discovery step
- Participants
- 943 vs 1,149
- Comparison
- CAD patients with T2D vs CAD patients without T2D
- CAD with T2Dn = 943
- CAD without T2Dn = 1,149reference
- Outcome
- Common genetic factors underlying T2D and CAD in CAD patients
Methodological detailsthree-step association approach, discovery, eliminating and replication steps, replication in UK Biobank
- Three-step association approach
- Discovery, eliminating and replication steps
- Replication in UK Biobank
Main finding
As reported in the abstract
Genetic loci associated with T2D in CAD patients
Genetic loci associated with T2D in CAD patients
10
Variants specific to either CAD or T2D
3
Variants losing significance after covariate adjustment
5
SNPs remaining associated with T2D in CAD patients (rs7904519*G: TCF7L2; rs17608766*C: GOSR2)
2
Further findings
Replication in UK Biobank
- Associations replicated in UK Biobank data
Original publication
Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes. Diabetes Res Clin Pract. Published 9 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →