Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age
Authors' conclusion
This study provides evidence of adiponectin as a biomarker of adverse metabolic health in youth. The association of methylation in CDH13, a gene involved in glucose regulation, with child adiponectin levels suggests a contribution to programming of future metabolic health.
Study context
- Population
- Children from the Hyperglycemia and Adverse Pregnancy Outcome Study and Follow-up Study with cord blood DNA methylation, anthropometry, adiponectin and OGTT glucose measures, mean age 11.4 ± 1.2 years
- Participants
- 2,265 children
- Outcome
- Association of cord blood DNA methylation (cbDNAm) with child adiponectin levels (epigenome-wide)
- Follow-up
- Mean age 11.4 ± 1.2 years
Methodological detailssecondary analysis of the HAPO Study and Follow-up Study, epigenome-wide association analysis, cross-sectional associations
- Secondary analysis of the HAPO Study and Follow-up Study
- Epigenome-wide association analysis
- Cross-sectional associations
Main finding
As reported in the abstract
Child adiponectin associations (adjusted)
- Partial correlation of log adiponectin with sum of skinfolds
- r = −0.285
- Partial correlation of log adiponectin with glucose sum of z-scores
- r = −0.070
- Partial correlation of log adiponectin with Matsuda index
- r = 0.135
- Partial correlation of log adiponectin with disposition index
- r = 0.062
- Cord blood DNA methylation (cbDNAm) at cg02713721 (CDH13 locus) associated with child adiponectin
- β = .35, Bonferroni-adjusted P = .01
Observational data: associations, not effects.
Original publication
Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age. J Clin Endocrinol Metab. Published 30 June 2025. doi:10.
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