Continuous Glucose Monitoring Profiles in Children Receiving High-Dose Glucocorticoid Treatment
Authors' conclusion
Two-thirds of investigated subjects developed GC-induced hyperglycemia. Participants experienced episodes of hyperglycemia regardless of the route of GC administration. The highest glucose values during 24 h were observed between 16:00 and 23:00 for patients receiving oral prednisolone and intravenous methylprednisolone. This observation is relevant to the optimal timing of screening for GC-induced hyperglycemia.
Study context
- Population
- Children receiving systemic GC at ≥1 mg/kg/day prednisolone-equivalent, monitored with continuous glucose monitoring (CGM), Tartu University Children's Clinic, December 2021–December 2024; mean age 10.5 years (range 4–17)2 boys · 8 girls
- Participants
- 10 children
- Outcome
- GC-induced hyperglycemia (SG above 10 mmol/L)
Methodological detailsretrospective analysis of blinded CGM data, single-centre, Average CGM duration 5 days (±2 days)
- Retrospective analysis of blinded CGM data
- Single-centre
- Average CGM duration 5 days (±2 days)
Main finding
As reported in the abstract
Children with GC-induced hyperglycemia (GIH)
7 of 10
Mean time per day with glucose above 10 mmol/L in those with GIH
1.5 h
Time above range (TAR) in those with GIH, average (±)
6%
±9%
Average CV (range 15 to 26%)
21%
Observational data: associations, not effects.
Original publication
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