Continuous glucose monitoring‐derived time in range is associated with changes in cognitive function test scores in Japanese patients with type 2 diabetes mellitus
Authors' conclusion
In patients with T2DM with undiagnosed dementia, CGM-derived TIR might be associated with overall cognitive decline and reduced processing speed.
Study context
- Population
- T2D patients aged ≥60 years with undiagnosed dementia, Japan
- Participants
- 197 patients
- Outcome
- Association between continuous glucose monitoring (CGM)-derived TIR and changes in cognitive function test scores (mini-mental state examination (MMSE), MoCA-J, digit symbol substitution test (DSST))
- Follow-up
- 2 years
Methodological detailsmulticentre, longitudinal
- Multicentre
- Longitudinal
Main finding
As reported in the abstract
Association of TIR with changes in cognitive test scores
Time in range (TIR) vs ΔMMSE, standard partial regression coefficient (β), p = 0.005
0.187
TIR vs ΔMoCA-J, β, p = 0.001
0.218
TIR vs ΔDSST, β, p = 0.036
0.164
Observational data: associations, not effects.
Original publication
Continuous glucose monitoring‐derived time in range is associated with changes in cognitive function test scores in Japanese patients with type 2 diabetes mellitus. Diabetes Obes Metab. Published 16 June 2025. doi:10.
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