Continuous Glucose Monitoring-Derived Glucometrics in Adults with Type 1 Diabetes When Switching Basal Insulins
Authors' conclusion
This retrospective real-world study reports that switching basal insulin significantly improved time spent in glucometric ranges and glycemic variability in the studied population of people with T1D.
Study context
- Population
- Adults with T1D switching to insulin degludec (IDeg) from other long-acting insulins; 61.5% men, mean age 47.4 (SD 16.9) years, diabetes duration 23.8 (14.2) years753 assessed
- Participants
- 486 adults
- Exposure
- After vs before switch to insulin degludec (IDeg) from other long-acting insulins
- Outcome
- Evolution of percent TIR (70-180 mg/dL or 3.9-10.0 mmol/L) before vs after switch to IDeg
- Follow-up
- 12 months
Methodological detailsmulticentre, real-world, before-after (12-month pre-switch vs 12-month follow-up)
- Multicentre
- Real-world
- Before-after (12-month pre-switch vs 12-month follow-up)
Main finding
As reported in the abstract
TIR over 24 h · 12 months vs baseline
P < 0.001
Observational data: associations, not effects.
Further findings
Time <54 mg/dL (<3.0 mmol/L) over 24 h · 12 months vs baseline · decreased, mostly during nighttime
P < 0.001
HbA1c · 12 months vs baseline · improved
P < 0.001
CV · 12 months vs baseline · improved
P < 0.001
- Mean daily basal, bolus and total insulin doses · 12 months vs baseline · decreased
- P < 0.001 for all vs. baseline
Original publication
Continuous Glucose Monitoring-Derived Glucometrics in Adults with Type 1 Diabetes When Switching Basal Insulins. Diabetes Technol Ther. Published 9 April 2024. doi:10.
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