Continuous glucose monitoring and intrapersonal variability in fasting glucose
An erratum to this article was published (Nat Med, May 2024 ↗)
Authors' conclusion
Our findings suggest that careful consideration is necessary when interpreting FG as substantial intraperson variability exists and highlight the potential impact of using CGM data to refine glycemic status assessment.
Study context
- Population
- Nondiabetic adults aged 40–70 years with continuous glucose monitoring (CGM)-measured fasting glucose (FG)59,565 morning windows
- Participants
- 8,315 adults
- Outcome
- FG measured by CGM and intraperson day-to-day FG variability
Main finding
As reported in the abstract
Mean FG (mean ± SD)
96.2 ± 12.87 mg dl-1
FG rise with age, per year
0.234 mg dl-1
Intraperson day-to-day FG SD
7.52 ± 4.31 mg dl-1
Days per participant
7.16 ± 3.17
Observational data: associations, not effects.
Further findings
Reclassification of individuals with normal FG on first measurement, by sequential measurements
- Individuals with normal FG on first measurement
- 5,328
- Reclassified to prediabetes range
- 40%
- Reclassified to diabetes range
- 3%
Associations between mean FG and clinical measures
- Associations revealed between mean FG and various clinical measures
Original publication
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