Congenital Hypothyroidism: Long‐Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose
Authors' conclusion
We demonstrated the favourable long-term outcomes in linear growth and neurodevelopment among children with CH, even in lower initial Levothyroxine doses.
Study context
- Population
- Children diagnosed with congenital hypothyroidism who received LT4 at Ajou University Hospital, 2003–2024
- Participants
- 144 children
- Exposure
- Low vs high initial LT4 dose
- Low dosen = 84
- Outcome
- Growth outcomes over time:
- Biennial evaluation
- Ages 4 to 8
- Follow-up
- Ages four to eight
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Most children in both dose groups showed appropriate growth within the normal range; no significant differences between low- and high-dose groups
- Low dose vs High dose: P = 0.545 for bone age-chronological age
- Low dose vs High dose: P = 0.609 for height z-score
- Low dose vs High dose: P = 0.532 for weight z-score
- Low dose vs High dose: P = 0.501 for BMI z-score
- Repeated-measures analysis of covariance
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Full-scale IQ (Wechsler)Effect of initial dose group not statistically significant · multivariate linear regression | P = 0.362 |
Original publication
Congenital Hypothyroidism: Long‐Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose. Clin Endocrinol (Oxf). Published 15 September 2025. doi:10.
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