Comprehensive Analysis of the Association Between Sex Hormones and Body Mass Components Among Men Adults: Results From a Large Population‐Based Study
Authors' conclusion
Higher TT levels, BT levels, SHBG levels and T/E ratios are associated with lower body weight and improved body composition in young adult men (characterized by higher lean body mass, higher bone density and lower fat mass). The relationship is especially pronounced among relatively young, nonsmoking men.
Study context
- Population
- Adult men aged 20–85 years, US National Health and Nutrition Examination Survey
- Participants
- 3,759 men
- Outcome
- Association of sex hormones with body mass components
Methodological detailspopulation-based, NHANES, generalized linear model regression, Blood sample collection and testing time not fixed, no strict fasting; statistical methods used to minimize impact of random testing
- Population-based
- NHANES
- Generalized linear model regression
- Blood sample collection and testing time not fixed, no strict fasting; statistical methods used to minimize impact of random testing
Main finding
As reported in the abstract
- Higher TT, SHBG, BT and T/E ratios significantly associated with higher total lean mass, appendicular lean mass and bone mineral content, and lower weight, body mass index (BMI), total fat and trunk fat
- Higher E2 significantly associated with lower total lean mass and appendicular lean mass, and higher weight, BMI, total fat and trunk fat
Observational data: associations, not effects.
Further findings
Subgroup analysis
- Significant interaction effects of age and smoking history in the association between sex hormones and body mass components
Original publication
Comprehensive Analysis of the Association Between Sex Hormones and Body Mass Components Among Men Adults: Results From a Large Population‐Based Study. Clin Endocrinol (Oxf). Published 28 October 2024. doi:10.
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