Comparison of bone microstructure and strength in the distal radius and tibia between the different types of primary hypertrophic osteoarthropathy: an high-resolution peripheral quantitative computed tomography (HR-pQCT) study
Authors' conclusion
PHOAR1 patients had inferior bone microstructure and strength compared with PHOAR2 patients and HCs. Additionally, this study was the first to find differences in the bone microstructure between PHOAR1 and PHOAR2 patients.
Study context
- Population
- Male Chinese patients with primary hypertrophic osteoarthropathy (PHO), Peking Union Medical College Hospital
- Participants
- 27 PHO patients
- Exposure
- PHOAR1 and PHOAR2 vs healthy controls (HCs); PHOAR1 vs PHOAR2
- PHOAR1n = 7
- PHOAR2n = 20
- Outcome
- Bone microarchitecture and strength (HR-pQCT, distal radius and tibia) in PHOAR1 and PHOAR2 vs HCs
Methodological detailsage- and sex-matched healthy controls, single-centre
- Age- and sex-matched healthy controls
- Single-centre
Main finding
As reported in the abstract
Bone microarchitecture and strength vs HCs
- PHOAR1 and PHOAR2 vs HCs: distinctively larger bone geometry, substantially lower vBMD at radius and tibia, compromised cortical microstructure at radius
- PHOAR1: significant deficits in tibial trabecular compartment, lower estimated bone strength
- PHOAR2 vs HCs: higher trabecular number, narrower trabecular separation, lower trabecular network inhomogeneity at tibia; preserved or slightly high estimated bone strength
Observational data: associations, not effects.
Further findings
- PHOAR1 had inferior bone microstructure and strength compared with PHOAR2
Original publication
Comparison of bone microstructure and strength in the distal radius and tibia between the different types of primary hypertrophic osteoarthropathy: an HR-pQCT study. Osteoporos Int. Published 18 May 2023. doi:10.
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