Moderate COVID‐19 Disease Is Associated With Reduced Bone Turnover
Authors' conclusion
Given this limitation, the investigation showed that bone metabolism is altered but remains coupled in patients with moderately severe COVID-19.
Study context
- Population
- Hospitalized patients with moderately severe COVID-19 (CRP median 16.0 [4.0; 52.8] mg/L), sampled at hospital admission; median age 67 [53; 81] years14 female and 11 male patients
- Comparison
- COVID-19 patients vs noninfected controls
- Outcome
- Coupling of bone metabolism: serum bone turnover markers (CTX, TRAP, osteocalcin, bone-specific alkaline phosphatase, sclerostin, dickkopf-1, osteoprotegerin)
- Follow-up
- Hospital admission
Methodological detailsage- and sex-matched, matched-pair analysis, Patients and controls recruited from different hospitals
- Age- and sex-matched
- Matched-pair analysis
- Patients and controls recruited from different hospitals
Main finding
As reported in the abstract
Serum bone turnover markers
- Sclerostin and dickkopf-1 significantly higher in infected patients vs controls
- Remaining parameters did not differ between cases and controls
- COVID-19 vs Controls: P = 0.011
- COVID-19 vs Controls: P = 0.025
- Matched-pair analysis
Observational data: associations, not effects.
Original publication
Moderate COVID‐19 Disease Is Associated With Reduced Bone Turnover. J Bone Miner Res. Published 18 May 2023. doi:10.
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