Plasma Levels of Branched Chain Amino Acids, Incident Hip Fractures, and Bone Mineral Density of the Hip and Spine
Authors' conclusion
Plasma levels of the BCAA leucine may be associated with higher BMD in older men and women. However, given the lack of significant association with hip fracture risk, further information is needed to determine whether BCAAs would be novel targets for osteoporosis therapies.
Study context
- Population
- Older African American and Caucasian men and women in the Cardiovascular Health Study, community setting; mean age 73 years38% men
- Participants
- 1,850 participants
- Exposure
- Plasma branched chain amino acids (BCAA) levels per 1 SD higher
- Outcome
- Incident hip fractures and cross-sectional BMD of the total hip, femoral neck and lumbar spine
- Follow-up
- 12 years
Methodological detailslongitudinal analyses of incident hip fractures, cross-sectional analyses of bone mineral density (BMD)
- Longitudinal analyses of incident hip fractures
- Cross-sectional analyses of BMD
Main finding
As reported in the abstract
over 12 years of follow-up
- Leucine positively and significantly associated with total hip BMD
- P = .03
- Leucine positively and significantly associated with femoral neck BMD
- P = .02
- Leucine not significantly associated with lumbar spine BMD
- P = .07
Observational data: associations, not effects.
Original publication
Plasma Levels of Branched Chain Amino Acids, Incident Hip Fractures, and Bone Mineral Density of the Hip and Spine. J Clin Endocrinol Metab. Published 18 May 2023. doi:10.
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