Comparative prognostic value of nine cardiorenal biomarkers for mortality among adults with prediabetes and diabetes
Authors' conclusion
Among nine evaluated cardiorenal biomarkers, NT-proBNP, hs-cTnT, and cystatin C demonstrated the strongest and most consistent associations with all-cause and CCD mortality among adults with prediabetes and diabetes, as well as the highest incremental predictive value. These biomarkers may serve as key components in future risk stratification models for individuals with prediabetes or diabetes.
Study context
- Population
- Adults with prediabetes or diabetes from NHANES 1999–2004, mortality follow-up through 2019
- Participants
- 4,087 adults
- Exposure
- Nine cardiorenal biomarkers compared for prognostic value for mortality
- Outcome
- All-cause and CCD mortality
- Follow-up
- Median 16.5 years
Methodological detailsNHANES 1999-2004, survey-weighted Cox proportional hazards models, time-dependent ROC analysis, weighted quantile sum regression
- NHANES 1999-2004
- Survey-weighted Cox proportional hazards models
- Time-dependent ROC analysis
- Weighted quantile sum regression
Main finding
As reported in the abstract
All-cause mortality (fully adjusted models)
- All-cause deaths
- 1855
- Cardio-cerebrovascular disease (CCD) deaths
- 630
- NT-proBNP, HR
- 2.19 (1.73-2.78) (95% CI)
- hs-cTnT, HR
- 2.30 (1.63-3.24) (95% CI)
- hs-cTnI, HR
- 1.80 (1.44-2.24) (95% CI)
- Cystatin C, HR
- 1.76 (1.36-2.28) (95% CI)
- β2-microglobulin, HR
- 1.72 (1.36-2.16) (95% CI)
- UACR, HR
- 1.50 (1.23-1.81) (95% CI)
Observational data: associations, not effects.
Further findings
Discrimination for 10-year mortality (time-dependent ROC)
- NT-proBNP and hs-cTnT AUCs, all-cause mortality
- 0.80 and 0.81
- NT-proBNP and hs-cTnT AUCs, CCD mortality
- both 0.85
- Adding NT-proBNP or hs-cTnT to base model significantly improved predictive accuracy
- NT-proBNP and hs-cTnT demonstrated the strongest discrimination
Biomarker mixture (weighted quantile sum (WQS) regression)
- All-cause mortality, HR
- 1.56 (1.32-1.84) (95% CI)
- CCD mortality, HR
- 1.39 (1.14-1.70) (95% CI)
- NT-proBNP, hs-cTnT and cystatin C contributed most strongly
Original publication
Comparative prognostic value of nine cardiorenal biomarkers for mortality among adults with prediabetes and diabetes. Diabetes Obes Metab. Published 13 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →