Comorbidity in Congenital Hypothyroidism—A Nationwide, Population-based Cohort Study
Authors' conclusion
CH patients have more neonatal morbidity and congenital malformations than their matched controls. The cumulative incidence of neurological disorders is higher in CH patients. However, our results do not support the existence of severe psychiatric comorbidity.
Study context
- Population
- Full-term patients with primary congenital hypothyroidism and matched controls from national population-based registers in Finland; median follow-up 11.6 years (range 0–23)
- Exposure
- Primary congenital hypothyroidism (CH) patients vs matched controls
- Outcome
- Incidence of congenital malformations, comorbidities and use of prescribed drugs
Methodological detailsnationwide, register-based, matched controls
- Nationwide
- Register-based
- Matched controls
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Neonatal jaundice
P < 0.001
Neonatal hypoglycemia
P < 0.001
Neonatal metabolic acidemia
P = 0.007
Neonatal respiratory distress
P < 0.003
Hearing loss and specific developmental disorders
- Cumulative incidence higher in CH patients than controls
Antidepressant and antipsychotic drug use
- Similar in CH patients and controls
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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