Combining an Electrochemical Continuous Glucose Sensor With an Insulin Delivery Cannula: A Feasibility Study
Authors' conclusion
Insulin delivery and glucose sensing with the investigational CGM-IS was feasible. Longer duration studies are needed.
Study context
- Population
- Adults with T1D
- Participants
- 12 adults
- Comparison
- Investigational combined CGM and insulin delivery cannula (CGM-IS) vs commercial insulin set (run-in)
- CGM-ISn = 12
- Outcome
- CGM-IS glucose accuracy vs YSI
Methodological detailsDexcom G6 worn post-consent to study end, Standardized test meal on mornings of days 1 and 4; venous samples every 10 minutes for YSI benchmarking
- Dexcom G6 worn post-consent to study end
- Standardized test meal on mornings of days 1 and 4; venous samples every 10 minutes for YSI benchmarking
Main finding
As reported in the abstract
| Group | Mean absolute relative difference (MARD) | Paired data points | Consensus error grid zone A | Consensus error grid zone A + B | Mean (SD) % bias | Within ±15 mg/dL or ±15% | Within ±20 mg/dL or ±20% |
|---|---|---|---|---|---|---|---|
| CGM-IS | 9.2% | 484 | 88.6% | 100% | −3.5 (11.7) % | 81.4% | 89.9% |
CGM-IS
Mean absolute relative difference (MARD)9.2%
Paired data points484
Consensus error grid zone A88.6%
Consensus error grid zone A + B100%
Mean (SD) % bias−3.5 (11.7) %
Within ±15 mg/dL or ±15%81.4%
Within ±20 mg/dL or ±20%89.9%
- Paired YSI readings <100 mg/dL
- 35
- Paired YSI readings ≥100 mg/dL
- 449
Further findings
Mean Dexcom glucose · run-in vs between meal tests
P = 0.39
Mean total daily insulin delivered by pump · run-in vs between meal tests
P = 0.47
Safety
- Cannula occlusions requiring discontinuation of insulin delivery: one at 70 hours post insertion and another during the day 4 meal test
- 2
Original publication
Combining an Electrochemical Continuous Glucose Sensor With an Insulin Delivery Cannula: A Feasibility Study. J Diabetes Sci Technol. Published 16 March 2024. doi:10.
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