Closed-Loop Insulin Delivery Systems for People with Type 1 Diabetes and Chronic Very Poor Metabolic Control: It Works and Is Safe!
Study context
- Population
- Patients aged >18 years with T1D and hemoglobin A1c (HbA1c) >11% (97 mmol/mol) before hybrid closed-loop (HCL); aged 18–49 yearseligible
- Participants
- 65 patients
- Exposure
- HCL in patients with T1D and very poor metabolic control
- HCLn = 32
- Outcome
- Percentage of patients who would agree to be treated with HCL
Methodological detailssingle center
- Single center
Main finding
As reported in the abstract
Already used or accepted to start HCL
HCL
50%
32
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| HbA1c · baseline | HCL mean 12.5 (SD 1.8) % | |
| HbA1c · up to 1 yearHCL at 1 year vs HCL at baseline · decreased | HCL mean 9.4 (SD 1.9) % | P < 0.001 |
| Still using HCL · up to 1 year | HCL 78% |
- HbA1c: 113 ± 20 mmol/mol
- HbA1c: 79 mmol/mol
- HbA1c: in 25 patients still using HCL
Safety
Acute metabolic events · up to 1 year
- Rate similar during the year of follow-up to the 3 years before HCL initiation
Original publication
Closed-Loop Insulin Delivery Systems for People with Type 1 Diabetes and Chronic Very Poor Metabolic Control: It Works and Is Safe! Diabetes Technol Ther. Published 11 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →