The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort
Authors' conclusion
The PANOMEN-3 score is useful in clinical practice, aiding physicians to better plan patient follow-up, as well as to manage residual disease and treatment strategies post-surgery.
Study context
- Population
- Surgically treated patients with pituitary adenoma, single center; PANOMEN-3 classification applied 6 months after surgery
- Participants
- 289 participants
- Exposure
- PANOMEN-3 grades 1, 2 and 3 vs grade 0
- Grade 0n = 9reference
- Grade 1n = 101
- Grade 2n = 140
- Grade 3n = 39
- Outcome
- Surgical outcome, disease recurrence or progression by PANOMEN-3 grade
Methodological detailslongitudinal, observational, single center
- Longitudinal
- Observational
- Single center
Main finding
As reported in the abstract
Risk of recurrent/residual disease
Each group vs grade 0Odds ratio (95% CI)
Grade 1
1.4(1.2–1.7)
Grade 2
1.5(1.2–1.9)
Grade 3
5.7(2.7–12.5)
Observational data: associations, not effects.
Further findings
Status at last follow-up (whole cohort)
- Disease-free
- 186 (64.4%)
- Stable residual
- 93 (32.5%)
- Recurrence and/or progression
- 9 (3.1%)
Original publication
The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort. Pituitary. Published 7 September 2025. doi:10.
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