Urinary incontinence as a novel and underrecognized clinical manifestation of prolactinoma in women
Authors' conclusion
Prolactinoma, particularly in the later stages of the disease, may influence detrusor muscle activity in female patients and contribute to an increased prevalence of UI.
Study context
- Population
- Women with prolactinoma and controls; UI assessed with the International Consultation on Incontinence Questionnaire-Short Form
- Participants
- 64 vs 80
- Exposure
- Women with prolactinoma vs controls
- Prolactinoman = 64
- Controlsn = 80reference
- Outcome
- Overall rate of urinary incontinence (UI)
Main finding
As reported in the abstract
Overall UI
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| UI subtypes: urge (UUI), mixed (MUI), stress (SUI)Prolactinoma vs Controls · higher with Prolactinoma | P = 0.012 |
| UI subtypes: urge (UUI), mixed (MUI), stress (SUI)Prolactinoma vs Controls · higher with Prolactinoma | P = 0.008 |
| UI subtypes: urge (UUI), mixed (MUI), stress (SUI)Prolactinoma vs Controls · no difference | P = 0.839 |
| Incontinent vs continent prolactinoma patientsIncontinent vs Continent · higher with Incontinent | P = 0.015 |
| Incontinent vs continent prolactinoma patientsIncontinent vs Continent · greater with Incontinent | P = 0.038 |
| Incontinent vs continent prolactinoma patientsIncontinent vs Continent · longer with Incontinent | P < 0.001 |
Incontinent vs continent prolactinoma patients
- Logistic regression: disease duration was the only independent predictor of UI in prolactinoma patients
Original publication
Urinary incontinence as a novel and underrecognized clinical manifestation of prolactinoma in women. Pituitary. Published 30 August 2025. doi:10.
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