Assessing the clinical application of the PANOMEN 3 classification in a large cohort of pituitary tumors
Authors' conclusion
In the postoperative setting, PANOMEN 3 classification is useful in prediction of recurrence and need for further therapy. However, it was a weaker tool for predicting recurrence than the French classification.
Study context
- Population
- Pituitary tumors surgically resected at Westmead Hospital, 2011–2018, examined per 2022 WHO Classification
- Participants
- 215 participants
- Exposure
- PANOMEN 3 grades 1–3 vs grade 0; PANOMEN 3 vs French clinicopathological classification
- Outcome
- Recurrence by PANOMEN 3 grade
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Recurrence
Each group vs grade 0Hazard ratio (95% CI)P value
Grade 3
10.99(1.14–106.11)
P = 0.038Grade 2
7.85(1.06–58.31)
P = 0.044Observational data: associations, not effects.
Further findings
Need for further intervention
- Proportion needing further intervention greater with higher PANOMEN 3 grades; interventions occurred earlier in high grade tumors
Recurrence: French classification vs PANOMEN 3, mutually adjusted
- French classification significant predictor adjusted for PANOMEN 3
- P < 0.001
- PANOMEN 3 not a strong predictor adjusted for French classification
- P = 0.374
Original publication
Assessing the clinical application of the PANOMEN 3 classification in a large cohort of pituitary tumors. Eur J Endocrinol. Published 27 June 2025. doi:10.
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