Clinical Outcomes in Pediatric Patients With Type 1 Diabetes With Early Versus Late Diagnosis: Analysis From the DPV Registry
Authors' conclusion
Early clinical diagnosis of type 1 diabetes may be beneficial for metabolic control and remission after 3 years of follow-up. Patients diagnosed early may represent a distinct group with better resources or with a different disease biology and slower β-cell destruction, which needs further evaluation.
Study context
- Population
- Pediatric patients with T1D diagnosed 2015–2019, DPV registry; median age at diagnosis 9.8 years (IQR 6.8; 13.0)
- Participants
- 14,292 patients
- Exposure
- Early vs intermediate vs late diagnosis vs diabetic ketoacidosis (DKA) at diagnosis
- Outcome
- Combined glucose indicator (CGI; laboratory HbA1c and CGM-estimated HbA1c)
- Follow-up
- 3 years after diagnosis
Methodological detailsDPV registry
- DPV registry
Main finding
As reported in the abstract
Early diagnosis vs Late diagnosis: P < 0.001 · Early diagnosis vs DKA: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Early diagnosis | Intermediate diagnosis | Late diagnosis | DKA | P value |
|---|---|---|---|---|---|
| Partial remission (insulin dose-adjusted CGI <9%) · 3 years after diagnosisEarly diagnosis vs Late diagnosis · more partial remission with early diagnosis | 12.6% (95% CI 11.0–14.4) | 11.7% (95% CI 10.2–13.5) | 9.1% (95% CI 7.7–10.7) | 8.6% (95% CI 7.3–10.0) | P < 0.001 |
| Partial remission (insulin dose-adjusted CGI <9%) · 3 years after diagnosisEarly diagnosis vs DKA · more partial remission with early diagnosis | P < 0.001 |
Original publication
Clinical Outcomes in Pediatric Patients With Type 1 Diabetes With Early Versus Late Diagnosis: Analysis From the DPV Registry. Diabetes Care. Published 26 August 2024. doi:10.
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