Clinical features of androgen abuse withdrawal in men during the first year of cessation: a community dwelling study
Authors' conclusion
Among men in the first year after stopping androgen abuse, psychological symptoms and reduced quality-of-life were most strongly associated with psychiatric comorbidity than biochemical recovery.
Study context
- Population
- Community-dwelling men: androgen nonusers, current users, or past users who had ceased within the last 12 months
- Participants
- 247 men
- Exposure
- Past androgen users vs current users vs nonusers
- Nonusersn = 50reference
- Current usersn = 125
- Past usersn = 72
- Outcome
- Symptom severity (mood, anxiety, sexual function, quality of life) and relation to biochemical recovery
- Follow-up
- First year after cessation
Methodological detailscommunity-dwelling
- Community-dwelling
Main finding
As reported in the abstract
- Psychiatric comorbidity independently associated with depression (multivariable)
- P = .001
- Psychiatric comorbidity independently associated with anxiety (multivariable)
- P < .001
- Psychiatric comorbidity independently associated with poorer quality of life (multivariable)
- P < .05
- Older age and higher LH associated with reduced sexual function
- P < .05
- Lower testosterone only modestly associated with depressive symptoms
- P = .03
Observational data: associations, not effects.
Further findings
Self-reported psychiatric diagnoses
- Self-reported psychiatric diagnoses higher among current and past users than nonusers
- 2.5-fold
Total testosterone
- Total testosterone highest in current users
- P < 0.001
- No difference in total testosterone between past users and nonusers
Original publication
Clinical features of androgen abuse withdrawal in men during the first year of cessation: a community dwelling study. J Clin Endocrinol Metab. Published 12 March 2026. doi:10.
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