Clinical Features and Outcomes of Myxedema Coma in Patients Hospitalized for Hypothyroidism: Analysis of the United States National Inpatient Sample
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 9.92 CI 5.69–17.28Authors' conclusion
In summary, MC remains a clinically significant diagnosis in the modern era, independently associated with high mortality and health care costs.
Study context
- Population
- Adults hospitalized for hypothyroidism in US nonfederal hospitals, National Inpatient Sample 2016–2018
- Participants
- 18,635 adults
- Exposure
- Myxedema coma vs hypothyroidism without myxedema coma (MC)
- MCn = 2,495
- Outcome
- In-hospital mortality
Methodological detailsNational Inpatient Sample, 2016-2018
- National Inpatient Sample, 2016-2018
Main finding
As reported in the abstract
Adjusted odds ratio
9.92
CI 5.69–17.28
P < 0.001
By group
MCvs nonMChypo
aOR 9.92 (CI 5.69–17.28); P < 0.001
Observational data: associations, not effects.
Further findings
LOS
P < 0.001
| Outcome | MC | nonMChypo | P value |
|---|---|---|---|
| Total hospital cost | $21,768 (SE $1759) | $8941 (SE $276) | P = 0.07 |
- Prevalence of MC among patients hospitalized for hypothyroidism
- 13.4% · 2495
Length of stay (LOS)
- MC an independent predictor of increased LOS (linear regression)
Total hospital cost
- MC an independent predictor of increased total hospital cost (linear regression)
Patient characteristics
- MC associated with older age
- P = 0.02
- MC associated with public insurance
- P = 0.01
- MC associated with unhoused status
- P = 0.04
- More MC admissions in winter vs other seasons
- P = 0.01
- Sex and race/ethnicity similar between MC and nonMChypo
Original publication
Clinical Features and Outcomes of Myxedema Coma in Patients Hospitalized for Hypothyroidism: Analysis of the United States National Inpatient Sample. Thyroid. Published 28 February 2024. doi:10.
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