Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature
Authors' conclusion
68 Ga-DOTATATE PET/CT could serve as the first diagnostic tool in patients with vertebral TIO, and segmental resection could be used as the preferred surgery. This study would raise awareness of the clinical features and management of these rare vertebral TIO patients.
Study context
- Population
- Adults with tumor-induced osteomalacia (TIO) with vertebral lesions, all operated, Peking Union Medical College Hospital
- Participants
- 16 adults
- Exposure
- Segmental resection vs tumor curettage
- Outcome
- Recovery rate after surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Tumor detection sensitivity: 68Ga-DOTATATE PET/CT vs 99Tcm-OCT
- Sensitivity of 68Ga-DOTATATE PET/CT, significantly greater than 99Tcm-OCT
- 100%
- Sensitivity of 99Tcm-OCT
- 40%
Baseline biochemistry
- Lower serum phosphorus and TmP/GFR, higher serum alkaline phosphatase (ALP), parathyroid hormone (PTH) and β-CTX than the normal range
Prognosis by vertebral site
- In thoracic and sacral vertebrae, segmental resection had a good prognosis
Original publication
Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature. Osteoporos Int. Published 2 August 2024. doi:10.
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