Clinical Characteristics of Adipsic Diabetes Insipidus
Authors' conclusion
ADI patients were found with higher prevalence of hypernatremia, hypopituitarism, hypothalamic dysfunction, metabolic disorders, and complications, posing a great challenge for comprehensive management.
Study context
- Population
- Hospitalized CDI patients, Endocrinology Department of Huashan Hospital, January 2014–December 2021
- Participants
- 507 hospitalized CDI patients
- Exposure
- Adipsic diabetes insipidus (ADI) vs CDI with normal thirst
- ADIn = 50
- Outcome
- Clinical features of ADI vs control
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- ADI
- Hypothalamic dysfunction 76% vs 8%; P < 0.001
- ADI
- Central hypothyroidism 100% vs 90%; P = 0.031
- ADI
- Hyperglycemia 66% vs 32%; P < 0.001
- ADI
- Dyslipidemia 92% vs 71%; P = 0.006
- ADI
- Hyperuricemia 64% vs 37%; P = 0.003
- ADI
- Suprasellar lesion 100% vs 66%; P < 0.05
- ADI
- Hypernatremia at admission 90% vs 8%; P < 0.001
- ADI
- Hypernatremia at discharge 68% vs 8%; P < 0.001
- ADI share of hospitalized CDI patients
- 9.9%
- ADI admitted due to hypernatremia (none in control)
- 40%
Observational data: associations, not effects.
Safety
- Higher prevalence of complications (renal insufficiency, venous thrombosis, infection) in ADI
Original publication
Clinical Characteristics of Adipsic Diabetes Insipidus. Endocr Pract. Published 27 November 2023. doi:10.
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