Incidence of postoperative hyponatremia after endoscopic endonasal pituitary transposition for skull base pathologies
An erratum to this article was published (Pituitary, Feb 2024 ↗)
Authors' conclusion
More than half of patients who had pituitary transposition developed transient hyponatremia. Hyponatremia was more common in those with narrower sellar access angle and smaller cranial extension of the tumor above the sellar floor. Anatomical/surgical parameters may allow risk-stratification for post-operative hyponatremia following pituitary transposition.
Study context
- Population
- Patients who underwent endoscopic endonasal surgery with pituitary transposition for non-pituitary derived tumors over a decade, University of Pittsburgh Medical Center
- Participants
- 72 patients
- Outcome
- Incidence of postoperative hyponatremia
- Follow-up
- Postoperative day 1, 3, 5, 7, and 10
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Developed post-operative transient hyponatremia
55.6%
Observational data: associations, not effects.
Further findings
Severe hyponatremia (sodium <120 mmol/L)
- Severe hyponatremia
- 2 (5%)
Desmopressin requirement
- Required desmopressin immediately post-operatively
- 11 (15.3%)
- Needed desmopressin after discharge and after sodium nadir
- 2
Anatomical/surgical parameters associated with hyponatremia
- Hyponatremia inversely associated with sellar access angle
- P = 0.02
- Tumor cranial extension above sellar floor: trend towards significance
- P = 0.09
Original publication
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