Clinical characteristics and cardiometabolic association of non-suppressed cortisol after dexamethasone suppression test in patients with pheochromocytoma
Main finding · T2DResult — go to the resultOdds ratio 2.072 95% CI 1.137–3.777Authors' conclusion
Larger tumor size, bilaterality, and higher plasma metanephrine and normetanephrine levels were associated with non-suppressed post-ODST cortisol. Post-ODST cortisol >1.8 μg/dL in patients with pheochromocytoma was independently linked to a higher prevalence of T2DM and HTN, suggesting an additive cardiometabolic burden.
Study context
- Population
- Patients with pheochromocytoma from 5 tertiary centers who underwent a 1-mg overnight dexamethasone suppression test (ODST)of 806 with pheochromocytoma
- Participants
- 389 patients
- Exposure
- Non-suppressed vs suppressed post-ODST cortisol in pheochromocytoma
- Non-suppressed cortisoln = 144
- Outcome
- T2D
Methodological detailsmulticenter, 5 tertiary centers
- Multicenter
- 5 tertiary centers
Main finding
As reported in the abstract
Odds ratio
2.072
95% CI 1.137–3.777
P = 0.017
By group
Non-suppressed cortisolvs Suppressed cortisol
OR 2.072 (95% CI 1.137–3.777); P = 0.017
Observational data: associations, not effects.
Further findings
Hypertension
P = 0.004
Bilaterality
P = 0.026
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| HypertensionIndependently associated (logistic regression) | 1.905 (1.079–3.361) | P = 0.026 | |
| 0.20.5125Odds ratio (log scale) |
Tumor size
P = 0.021
- Body mass index (BMI)
- P = 0.050
Prevalence of non-suppressed cortisol
- Non-suppressed cortisol identified
- 144 patients (37.0%)
BMI
- Comparable BMI
Correlation of post-ODST cortisol with catecholamines
- Plasma metanephrine, r (P = .011)
- 0.148
- Plasma normetanephrine, r (P = .016)
- 0.141
Original publication
Clinical characteristics and cardiometabolic association of non-suppressed cortisol after dexamethasone suppression test in patients with pheochromocytoma. Eur J Endocrinol. Published 19 May 2026. doi:10.
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