Comparison of salivary cortisol, cortisone, and dexamethasone with serum measurements across dynamic adrenal testing
Authors' conclusion
These findings support saliva-based dynamic adrenal testing and identify clinically relevant salivary thresholds.
Study context
- Population
- Adults undergoing dynamic adrenal testing at a tertiary referral center640 participants
- Participants
- 473 / 163 / 11
- Exposure
- Salivary cortisol, cortisone and dexamethasone vs serum measurements during dynamic adrenal testing
- Dexamethasone suppression testing (DST)n = 473
- Cosyntropin stimulation testing (CST)n = 163
- Overnight metyrapone testing (OMT)n = 11
- Outcome
- Correlation of salivary with serum measurements
Methodological detailstertiary referral center
- Tertiary referral center
Main finding
As reported in the abstract
Salivary cortisone vs serum cortisol after 1-mg DST, r
0.86
Salivary cortisol vs serum cortisol after 1-mg DST, r (both P < 0.001)
0.53
Salivary cortisol and cortisone vs serum cortisol during CST, r (all P < 0.001)
0.75-0.87
Salivary vs serum dexamethasone, r (P < 0.001)
0.61
Observational data: associations, not effects.
Further findings
Salivary cortisone thresholds corresponding to serum cortisol 1.8, 5, 10 and 18 µg/dL (50, 138, 276 and 497 nmol/L)
- Salivary cortisone thresholds, ng/dL
- 117, 329, 585, and 1262
- Salivary cortisone thresholds, nmol/L
- 3.25, 9.13, 16.23, and 35.01
Salivary cortisol thresholds corresponding to serum cortisol 1.8, 5, 10 and 18 µg/dL
- Salivary cortisol thresholds, ng/dL
- 16.5, 38, 80, and 278
- Salivary cortisol thresholds, nmol/L
- 0.46, 1.05, 2.21, and 7.67
Original publication
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