Adverse events During the Diagnostic Workup for Primary Aldosteronism
Authors' conclusion
Mild AEs are commonly associated with medication adjustment during screening for PA. Severe AEs with hospitalization or death are rare. AEs are also relatively rare during confirmatory and subtyping studies.
Study context
- Population
- Patients with hypertension tested for primary aldosteronism (PA) (ARR screening, saline suppression test, AVS)
- Participants
- 545 patients
- Exposure
- Medication adjustment vs no medication adjustment during PA screening
- Medication adjustmentn = 447
- No medication adjustmentn = 98reference
- Outcome
- Frequency and nature of AEs with medication adjustment during screening and with confirmatory and subtyping tests
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
AEs during screening
- Fatality with medication adjustment
- 1
- Required emergency care with medication adjustment
- 14 (3%)
- Hospitalization with medication adjustment
- 8 (2%)
- Required further medical counseling with medication adjustment
- 94 (21%)
Observational data: associations, not effects.
Further findings
Adverse events (AEs) with saline suppression test
- AEs with saline suppression test
- 5 of 267 (2%)
- Requiring hospitalization
- 1
AEs with AVS
- AEs with AVS
- 5% (6/119)
- Requiring cardiopulmonary resuscitation for asystole
- 1
Original publication
Adverse events During the Diagnostic Workup for Primary Aldosteronism. Endocr Pract. Published 24 September 2026. doi:10.
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