Circulating plasma follistatin follows a 24-hour rhythm in healthy young males
Authors' conclusion
Plasma follistatin displayed a significant 24-hour rhythm in our cohort of 22 healthy young men. Although meal intake, particularly protein, influences follistatin, it does not fully explain the observed rhythm.
Study context
- Population
- Healthy young men
- Participants
- 22 men
- Outcome
- Plasma concentrations of follistatin
- Follow-up
- 24 hours
Methodological details24-hour study, blood sampling every three hours, controlled research facility simulating normal daily life, Cosinor rhythmometry and 1-way repeated measures ANOVA
- 24-hour study
- Blood sampling every three hours
- Controlled research facility simulating normal daily life
- Cosinor rhythmometry and 1-way repeated measures ANOVA
Main finding
As reported in the abstract
Plasma follistatin 24-hour rhythm (cosinor)
Relative amplitude
18%
Rhythm adjusted average (mesor ± SD)
873 ± 25 pg/mL
Peak time
11:50 Am
Observational data: associations, not effects.
Original publication
Circulating plasma follistatin follows a 24-hour rhythm in healthy young males. J Clin Endocrinol Metab. Published 19 March 2026. doi:10.
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