Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity
Authors' conclusion
This study is the first to report the elevated circulating level of periostin in adults with OI and its association with disease severity.
Study context
- Population
- Adults with osteogenesis imperfecta and age-, sex-, and BMI-matched controls; serum periostin measured by ELISA
- Participants
- 61 vs 61
- Comparison
- Adults with osteogenesis imperfecta (OI) vs matched controls
- OIn = 61
- Controlsn = 61reference
- Outcome
- Serum periostin level
Methodological detailsage-, sex-, and BMI-matched
- Age-, sex-, and BMI-matched
Main finding
As reported in the abstract
Serum periostin
P = 0.017
Observational data: associations, not effects.
Further findings
Clinical variables associated with higher periostin among OI patients
- Female sex
- P = 0.01
- Presence of scoliosis
- P = 0.01
- Sillence type III
- P = 0.05
Correlation of periostin with height-wingspan discrepancy (OI)
- Pearson r
- r = 0.30, P = .023
Multivariable linear regression of periostin (OI)
- Number of severe fractures (femur/pelvis/humerus/vertebral), independently associated with higher periostin
- β = 25.6, P = .041
- Smoking, negatively associated
- β = −269.8, P = .012
Original publication
Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity. J Clin Endocrinol Metab. Published 17 March 2026. doi:10.
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