Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly
Main finding · i-VFsResult — go to the resultOdds ratio 0.16 95% CI 0.03–0.79Authors' conclusion
It is likely that D3 supplementation could lead to a reduction in i-VFs in acromegaly.
Study context
- Population
- Patients with acromegaly
- Participants
- 61 patients
- Exposure
- D3 supplementation vs no D3 supplementation
- D3n = 26
- Outcome
- Incident morphometric vertebral fractures (i-VFs)
- Follow-up
- Last
Methodological detailslongitudinal, multicenter
- Longitudinal
- Multicenter
Main finding
i-VFs
Odds ratio
0.16
95% CI 0.03–0.79
P = 0.01
By group
D3vs No D3
OR 0.16 (95% CI 0.03–0.79); P = 0.01
As reported in the abstract
- Incident VFs (i-VFs) diagnosed, all patients
- 14 (23%)
Observational data: associations, not effects.
Further findings
Final serum 25(OH)D by i-VF status
- Patients who developed i-VFs, median (IQR)
- 28.6 ng/mL (IQR: 4.1)
- Patients without i-VFs, median (IQR)
- 34.2 ng/mL (IQR: 9.6)
- Significantly lower with i-VFs
- P = 0.05
D3 dosage and duration
- Median weekly D3 dosage
- 8500 IU (IQR: 3900)
- Median duration of D3 supplementation
- 94 months (IQR: 38)
Original publication
Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly. J Clin Endocrinol Metab. Published 22 August 2023. doi:10.
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