Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation
Authors' conclusion
Diagnosis of presymptomatic type 1 diabetes in children followed by education and monitoring improved clinical presentation at the onset of stage 3 type 1 diabetes.
Study context
- Population
- Children at diagnosis of stage 3 (clinical) T1D
- Participants
- 128 vs 736
- Exposure
- Children with prior presymptomatic (early-stage) T1D diagnosis via screening (Fr1da) vs children without prior screening (DiMelli)
- Fr1dan = 128
- DiMellin = 736reference
- Outcome
- Disease severity at onset of clinical (stage 3) T1D
- Follow-up
- Diagnosis of stage 3 T1D
Methodological detailscomparison with historical cohort without prior screening
- Comparison with historical cohort without prior screening
Main finding
As reported in the abstract
HbA1c
HbA1c · diagnosis of stage 3 T1D
HbA1c % Fr1da 6.8% · DiMelli 10.5%
- Fr1da vs DiMelli: P < 0.001 — lower with Fr1da
Observational data: associations, not effects.
Further findings
- Median fasting glucose at stage 3 diagnosis · diagnosis of stage 3 T1D — Median fasting glucose, prior early-stage diagnosis vs no previous early-stage diagnosis · Prior early-stage diagnosis vs No previous early-stage diagnosis · lower with prior early-stage diagnosis
- 5.3 mmol/l vs 7.2 mmol/l · P < 0.05
- Median fasting C-peptide at stage 3 diagnosis · diagnosis of stage 3 T1D — Median fasting C-peptide, prior early-stage diagnosis vs no previous early-stage diagnosis · Prior early-stage diagnosis vs No previous early-stage diagnosis · higher with prior early-stage diagnosis
- 0.21 nmol/l vs 0.10 nmol/l · P < 0.001
- Ketonuria at stage 3 diagnosis · diagnosis of stage 3 T1D — Ketonuria, prior early-stage diagnosis vs no previous early-stage diagnosis · Prior early-stage diagnosis vs No previous early-stage diagnosis · fewer with prior early-stage diagnosis
- 22.2% vs 78.4% · P < 0.001
- Insulin treatment required at stage 3 diagnosis · diagnosis of stage 3 T1D — Required insulin treatment, prior early-stage diagnosis vs no previous early-stage diagnosis · Prior early-stage diagnosis vs No previous early-stage diagnosis · fewer with prior early-stage diagnosis
- 72.3% vs 98.1% · P < 0.05
Associations of outcomes in children with prior early-stage diagnosis
- Outcomes not associated with family history of T1D or diagnosis during the COVID-19 pandemic
- Milder clinical presentation in children who participated in education and monitoring after early-stage diagnosis
Original publication
Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia. Published 17 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →