Childhood follow‐up of the GRoW randomized trial: Metformin in addition to dietary and lifestyle advice for pregnant women with overweight or obesity
Authors' conclusion
We did not show evidence of the benefit of metformin for children of women with overweight or obesity during pregnancy adding to the growing literature on the lack of effect of pregnancy interventions in reducing longer-term risks of childhood obesity.
Study context
- Population
- Children born to women with overweight or obesity who participated in the GRoW trial
- Participants
- 513 women
- Comparison
- In-utero metformin exposure vs placebo
- Primary endpoint
- BMI z-score >85th centile for age and sex
- Follow-up
- 6 and 18 months and 3 to 5 years of age
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
BMI >85th centile · all time points
- Number of children with BMI >85th centile similar between treatment groups at all time points
Further findings
BMI z-score >85th centile, all children · 18 months and 3 to 5 years
- More than half of children had BMI z-score >85th centile, indicating high risk of childhood obesity
Original publication
Childhood follow‐up of the GRoW randomized trial: Metformin in addition to dietary and lifestyle advice for pregnant women with overweight or obesity. Pediatr Obes. Published 12 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →