Characterization of primary hyperparathyroidism based on target organ involvement: An analysis from the Indian PHPT registry
Authors' conclusion
We observed distinct skeletal and renal phenotypic subgroups among PHPT patients with characteristic biochemical and hormonal patterns with higher parathyroid disease burden in patients with skeletal complications compared to those with isolated renal manifestation.
Study context
- Population
- PHPT patients in the Indian PHPT registryeligible
- Participants
- 229 patients
- Exposure
- PHPT phenotypes by target organ involvement: asymptomatic vs renal vs skeletal vs skeletal and renal
- Asymptomaticn = 45
- Renaln = 62
- Skeletaln = 55
- Skeletal and renaln = 67
- Outcome
- Serum calcium
Methodological detailsIndian PHPT registry
- Indian PHPT registry
Main finding
As reported in the abstract
P < 0.05
Observational data: associations, not effects.
Further findings
Serum alkaline phosphatase (AP), plasma parathyroid hormone (PTH) and parathyroid tumour weight
- Significantly higher in Skeletal and in Skeletal and renal vs the other two groups
Preoperative PTH and AP predicting skeletal involvement
- PTH 300 pg/mL: sensitivity, specificity
- 71%, 70%
- AP 152 U/L: sensitivity, specificity
- 69%, 67%
Original publication
Characterization of primary hyperparathyroidism based on target organ involvement: An analysis from the Indian PHPT registry. Clin Endocrinol (Oxf). Published 11 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →