Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users
Authors' conclusion
Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function.
Study context
- Population
- Recreational strength training men with and without a history of illicit androgen use; mean (SD) age 33 (8) years; geometric mean time since androgen cessation 1.9 (95% CI 1.2; 3.0) yearsRecreational strength training men with 30
- Participants
- 17 / 13 / 26
- Exposure
- Previous illicit androgen users vs nonusers
- Group 1n = 17
- Group 2n = 13
- Nonusersn = 26reference
- Outcome
- Testosterone secretion after hCG injection
Methodological detailsGnRH and hCG stimulation tests
- GnRH and hCG stimulation tests
Main finding
As reported in the abstract
Each group vs nonusersDifference, nmol/L (CI)P value
Group 1
−6.4(−11.3 to −1.5)
P = 0.031Group 2
−14.2(−19.5 to −8.8)
P < 0.001Observational data: associations, not effects.
Further findings
LH secretion
- LH secretion did not differ between the groups
Erectile function (multivariate linear regression)
- Higher testosterone secretion during hCG test independently associated with better erectile function
- P = 0.046
- Baseline serum testosterone not associated
- P = 0.780
- Estradiol not associated
- P = 0.405
Original publication
Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users. J Clin Endocrinol Metab. Published 7 March 2025. doi:10.
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