Changes in the combination of the triglyceride-glucose index and obesity indicators estimate the risk of cardiovascular disease
Authors' conclusion
Changes in TyG-related indices are independently associated with the risk of CVD. Changes in TyG-WC are expected to become more effective indicators for identifying individuals at a heightened risk of CVD.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study, exposures measured 2012 to 2015; 54.4% female, mean age 57.62 years at baseline
- Participants
- 3,243 participants
- Exposure
- Classes of changes in TyG-WC
- Outcome
- Incident CVD
- Follow-up
- 5-year follow-up
Methodological detailsK-means classification of index changes into four classes, multivariate logistic regression
- K-means classification of index changes into four classes
- Multivariate logistic regression
Main finding
As reported in the abstract
Incident CVD by changes in TyG-WC
Each group vs class 1Odds ratio (95% CI)
Class 2
1.41(1.08–1.84)
Class 3
1.54(1.15–2.07)
Class 4
1.94(1.34–2.80)
- Incident cardiovascular disease (CVD), all participants
- 637 (19.6%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Incident CVD by cumulative TyG-WC quartile · 5-year follow-upQuartile 2vs Quartile 1 | 1.33 (1.00–1.76) | |
| Incident CVD by cumulative TyG-WC quartile · 5-year follow-upQuartile 3vs Quartile 1 | 1.46 (1.09–1.96) | |
| Incident CVD by cumulative TyG-WC quartile · 5-year follow-upQuartile 4vs Quartile 1 | 1.79 (1.30–2.47) | |
| 0.512Odds ratio (log scale) |
Incident CVD by cumulative TyG-WC quartile · 5-year follow-up
- Cumulative TyG-WC showed the strongest association with incident CVD among cumulative triglyceride glucose (TyG)-related indices
Original publication
Changes in the combination of the triglyceride-glucose index and obesity indicators estimate the risk of cardiovascular disease. Cardiovasc Diabetol. Published 6 June 2024. doi:10.
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