Changes in continuous glucose monitoring metrics and predictors of improvement 12 months after conversion from Freestyle Libre to Freestyle Libre 2
Authors' conclusion
Conversion to Freestyle Libre 2 was associated with significant improvements in low glucose metrics. Alert function users were more likely to see improvements across all CGM metrics. Challenges remain in encouraging alert use, helping users set optimal alert thresholds and optimizing response to alerts.
Study context
- Population
- Adults with T1D converting from Freestyle Libre to Freestyle Libre 2
- Participants
- 672 adults
- Exposure
- Freestyle Libre 2 after conversion from Freestyle Libre
- Outcome
- Changes in CGM metrics
- Follow-up
- 12 months
Main finding
As reported in the abstract
Time below range (TBR) fell by a median of (IQR −2.7 to 0.3), p < 0.001
1.0%
Time in range (TIR) decreased by (−8.7 to 6.0), p = 0.004
1.0%
Average duration of low glucose events (<3.9 mmoL/L) fell by (−46 to 18), p < 0.001
10 min
Observational data: associations, not effects.
Secondary outcomes
Predictors of fall in TBR of ≥0.5% and rise in TIR of ≥5% · 12 months
| HR (95% CI) | P value | ||
|---|---|---|---|
| Low alert useFall in TBR of ≥0.5%; independently associated | 1.9 (1.2–3.1) | P = 0.009 | |
| High alert useRise in TIR of ≥5%; independently associated | 1.6 (1.0–2.5) | P = 0.043 | |
| 0.20.5125Hazard ratio (log scale) |
TIR in people using high glucose alerts
- TIR did not fall in high glucose alert users (p = 0.353)
- Significant improvements in TIR (p = 0.029) and time above 13.9 mM (p = 0.002) in high glucose alert users
Predictors of fall in TBR of ≥0.5% and rise in TIR of ≥5% · 12 months
- Alert threshold settings were not associated with glycaemic response
Original publication
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