Central precocious puberty in boys: secular trend and clinical features
Authors' conclusion
The estimated incidence of CPP in boys was 0.34 per 10 000, with 26% of cases associated with intracranial pathology. The increase in CPP incidence was driven by rising ICPP rates. Patients with OCPP were characterized by shorter stature, younger age, and higher basal testosterone levels, providing valuable cues for differentiation in addition to brain MRI. Utilizing multiple cues could guide diagnostic decision-making.
Study context
- Population
- Boys treated for central precocious puberty (CPP) at Helsinki University Hospital, 1985–2014
- Participants
- 43 participants
- Exposure
- Organic CPP vs idiopathic CPP
- Outcome
- Incidence of male CPP and clinical/auxological indicators of OCPP
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
CPP incidence in boys, 2010–2014
0.34 per 10 000
95% CI 0.20–0.60
Proportion with organic CPP (OCPP) on brain MRI
26%
Trend in male CPP incidence, 1990–2014 (IRR)
1.10
P = .001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Clinical features, OCPP vs ICPPOCPP vs ICPP · younger with OCPP | P = 0.006 |
| Clinical features, OCPP vs ICPPOCPP vs ICPP · shorter with OCPP | P = 0.003 |
| Clinical features, OCPP vs ICPPOCPP vs ICPP · higher basal serum testosterone with OCPP | P = 0.038 |
Idiopathic CPP (ICPP) incidence trend · 1990–2014
- ICPP incidence increased (IRR)
- 1.11, 95% CI 1.05-1.19, P < .001
- OCPP incidence remained stable
- P = 0.41
Combined clinical cues differentiating organic from idiopathic etiology
- Combining 2 to 4 cues: AUC (all), good to excellent
- 0.84-0.97, P < .001
Original publication
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