Carney complex predisposes to breast cancer: prospective study of 50 women
Authors' conclusion
As CNC could predispose to breast carcinoma, an adequate screening strategy and follow-up should be discussed in affected women.
Study context
- Population
- Women with Carney complex (CNC), French multicenter prospective study38 with breast imaging
- Participants
- 50 women
- Outcome
- Characteristics of breast lesions in CNC patients and their association with other CNC manifestations and PRKAR1A genotype
Methodological detailsmulticenter, 3-year follow-up
- Multicenter
- 3-year follow-up
Main finding
As reported in the abstract
Breast lesions among women with breast imaging
- Breast lesions
- 14 (39%)
- Breast lesions bilateral
- half of them
- Benign lesions
- 10 (26%)
- Breast carcinomas
- 6 (16%)
- Ductal carcinoma in situ at age 54
- 1
- Invasive cancer before 50 years old
- 5
- Breast cancer with PRKAR1A pathogenic variant vs general population of same age, OR
- 6.34 (1.63-17.91)
- Mean age at breast cancer diagnosis, years
- 44.7
- Younger than general population, years
- 17
Observational data: associations, not effects.
Further findings
Contralateral breast cancer during follow-up
- Women with invasive cancer who developed contralateral breast cancer
- 1
Prognosis and tumour genetics
- Loss of heterozygosity at PRKAR1A locus in invasive breast carcinomas analysed
- 2
- Breast cancer patients had good prognosis factors
- Suggested a driver role of this tumor suppressor gene
Original publication
Carney complex predisposes to breast cancer: prospective study of 50 women. Eur J Endocrinol. Published 22 January 2024. doi:10.
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