Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study
Authors' conclusion
In this national contemporary cohort, prophylactic-intent thyroidectomy in pediatric MEN2 was associated with excellent short-term oncologic outcomes but also with a substantial rate of permanent hypoparathyroidism, particularly in very young children.
Study context
- Population
- Children <15 years with MEN2 germline RET mutations who underwent prophylactic-intent total thyroidectomy 2010–2020 without clinically apparent structural disease, French Groupe d'Étude des Tumeurs Endocrines61 MEN2A, 3 MEN2B
- Participants
- 64 children
- Outcome
- Histopathology and oncologic status
- Follow-up
- Median 6 years (IQR = 2.4-8.5 years)
Methodological detailsnational, multicenter
- National
- Multicenter
Main finding
As reported in the abstract
- C-cell hyperplasia
- 52%
- Micro-MTC
- 34%
- Lymph node metastases
- 3%
- Persistent structural disease at last follow-up
- 0
- Persistent moderate biochemical disease without structural evidence of medullary thyroid carcinoma (MTC)
- 1 patient
Observational data: associations, not effects.
Further findings
Preoperative calcitonin elevated
- Elevated preoperative calcitonin, evaluable patients
- 44%
Age at surgery
- Median age at surgery, years (IQR = 3.2-8.3 years)
- 4.6
Safety
Postoperative hypoparathyroidism
- Hypoparathyroidism
- 31%
- Permanent hypoparathyroidism, predominantly among children operated before age 5 years
- 16%
Original publication
Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study. Thyroid. Published 7 August 2026. doi:10.
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