Cardiovascular risk profile in subjects with diabetes: Is SCORE2-Diabetes reliable?
Authors' conclusion
Higher PWV, IMT, and carotid atherosclerosis prevalence were associated with increasing CV risk stratified by SCORE2-Diabetes, with no significant differences between the very high and ASCVD/TOD groups. SCORE2-Diabetes demonstrated a better identification of preclinical vascular damage compared to SCORE2, supporting its use as a reliable tool for identifying vascular damage in T2D patients without ASCVD or TOD.
Study context
- Population
- Individuals with T2D aged 40–69 years
- Participants
- 179 individuals
- Exposure
- SCORE2-Diabetes risk classes and atherosclerotic cardiovascular disease (ASCVD)/target organ damage (TOD); SCORE2-Diabetes vs SCORE2
- Lown = 20reference
- Moderaten = 29
- Highn = 44
- Very highn = 37
- ASCVD/TODn = 49
- Outcome
- PWV
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| ROC: prediction of carotid atherosclerosis and high PWVSCORE2-Diabetes vs SCORE2 · superior predictive performance with SCORE2-Diabetes | P = 0.048 |
Intima-media thickness (IMT)
- IMT showed a stepwise increase with risk class
Carotid atherosclerosis prevalence
- Very high or ASCVD/TOD patients had a higher prevalence of carotid atherosclerosis than other groups
Very high vs ASCVD/TOD (all parameters)
- No significant differences between very high and ASCVD/TOD in any parameter
Correlation of pulse wave velocity (PWV) with increasing CV risk
- Correlation stronger for SCORE2-Diabetes than for SCORE2
Original publication
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