Cardiovascular Risk Markers in Adults With Adrenal Incidentaloma and Mild Autonomous Cortisol Secretion
Authors' conclusion
Adults with adrenal adenoma and MACS do not have fasting endothelial dysfunction and postprandial endothelial function may be better. These patients have fasting and postprandial hyperglycemia with lower insulin secretion, which may underlie the association between MACS and increased cardiovascular mortality.
Study context
- Population
- Adults with adrenal adenoma (mild autonomous cortisol secretion (MACS) or nonfunctioning)
- Participants
- 20 vs 20
- Exposure
- MACS vs nonfunctioning adrenal adenoma
- MACSn = 20
- Nonfunctioning adrenal adenoman = 20reference
- Outcome
- Difference in reactive hyperemia index (RHI), measured by peripheral artery tonometry, between MACS vs nonfunctioning adrenal adenoma
Main finding
As reported in the abstract
Fasting RHI
MACS
2.0
IQR 1.6–2.4
Nonfunctioning adrenal adenoma
2.0
IQR 1.7–2.2
P = 0.72
Observational data: associations, not effects.
Further findings
| Outcome | MACS | Nonfunctioning adrenal adenoma | P value |
|---|---|---|---|
| Postprandial RHIHigher with MACS | 2.2 (IQR 1.8–2.7) | 1.8 (IQR 1.5–2.2) | P = 0.04 |
24h ambulatory BP and Matsuda index
- 24h ambulatory BP and Matsuda index not significantly different between groups
Glycaemia and insulin secretion
- Fasting glucose and glucose AUC after mixed meal higher, insulinogenic index lower with MACS
Cortisol after 1-mg dexamethasone and UFC
- Higher with MACS
Original publication
Cardiovascular Risk Markers in Adults With Adrenal Incidentaloma and Mild Autonomous Cortisol Secretion. J Clin Endocrinol Metab. Published 15 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →