Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes: A Systemic Review and Meta-Analysis
Authors' conclusion
These findings suggest that deficits in CRF may be larger and more consistent in youths with T2D compared with youths with T1D, suggesting an increased risk for cardiovascular disease-related morbidity in adolescents with diabetes, particularly among those with T2D. The findings reinforce calls for novel interventions to empower youths living with diabetes to engage in regular physical activity and increase their CRF.
Study context
- Population
- Children and adolescents aged ≤18 years with T1D or T2D and a control group; observational studies, MEDLINE, Embase, CINAHL, SPORTDiscus, 2000–2022
- Comparison
- Youths with T1D or T2D vs youths without diabetes
- Outcome
- Objectively measured cardiorespiratory fitness (CRF) from a graded maximal exercise test, and subjective or objective measures of physical activity
Methodological detailsrandom-effects meta-analysis, PRISMA, Data extraction by 2 independent reviewers
- Random-effects meta-analysis
- PRISMA
- Data extraction by 2 independent reviewers
Pooled result
As reported in the abstract
Each group vs controlsSMD (95% CI)
T2DCRF; I2 = 84%; 9 studies; 755 participants
−1.06(−1.57 to −0.56)
T1DCRF; I2 = 89%; 22 studies; 2082 participants
−0.39(−0.70 to −0.09)
T1Dphysical activity, marginally lower; I2 = 89%; 31 studies; 12 196 participants
−0.29(−0.46 to −0.11)
T2Dphysical activity, not different; I2 = 91%; 9 studies; 1233 participants
−0.56(−1.28 to 0.16)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Physical activity, studies with objective measures onlyT2Dvs ControlsI2 = 23%; 3 studies; 332 participants | −0.71 (−1.36 to −0.05) | |
| Physical activity, studies with objective measures onlyT1Dvs ControlsI2 = 93%; 12 studies; 1357 participants | −0.67 (−1.17 to −0.17) | |
| −2−101Difference (linear scale) |
Original publication
Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes: A Systemic Review and Meta-Analysis. JAMA Netw Open. Published 5 February 2024. doi:10.
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