Association Between Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review
Authors' conclusion
While evidence does not support GLP-1 RAs as a causative agent for suicidality
Study context
- Population
- Adults using GLP-1 RAs; observational studies of suicidal ideation, suicide attempts or completed suicide (MEDLINE, PubMed, EMBASE, CINAHL, PsycINFO, inception to December 11, 2025)43 studies
- Comparison
- GLP-1 RA use and suicidal ideation or behaviours
- Outcome
- Suicidal ideation or behaviours
Methodological detailsduplicate independent screening, extraction and risk of bias assessment
- Duplicate independent screening, extraction and risk of bias assessment
Pooled result
As reported in the abstract
- Findings varied by study design
- Some case reports suggested a temporal relationship between GLP-1 RA use and suicidal ideation
- Cross-sectional and case-control studies: negative association between GLP-1 RAs and suicide attempts
- Pharmacovigilance and cohort studies: mixed results; some found a positive association between semaglutide or liraglutide and suicidal ideation, others a negative association with suicidal behaviours (attempts, intentional self-harm) or completed suicide
Original publication
Association Between Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review. Diabetes Obes Metab. Published 18 May 2026. doi:10.
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