Cancer Risk and its Association With Diabetes Mellitus in Patients With Acromegaly: A Two Center-based Study
Authors' conclusion
Acromegaly patients are at a higher risk of cancer and its association with diabetes mellitus. Considering the rarity of the disease, an Acromegaly Cancer Registry Center should be established in China as soon as possible.
Study context
- Population
- Patients diagnosed with acromegaly at 2 centers in China, 2011–2022
- Participants
- 117 patients
- Exposure
- Acromegaly patients vs local population in China; cancer vs no cancer
- Cancern = 8
- Outcome
- Cancer incidence vs local population (SIR)
Methodological detailstwo-centre, standardized incidence ratios vs local population
- Two-centre
- Standardized incidence ratios vs local population
Main finding
As reported in the abstract
Cancer incidence (SIR vs local population)
- Diagnosed with cancer
- 8 (6.8%) of 117
- Overall cancer SIR
- 3.29 (1.42-6.94) (95% CI)
- Colorectal cancer SIR
- 16.67 (4.45-42.67) (95% CI)
- Thyroid cancer SIR
- 14.29 (1.73-51.60) (95% CI)
- Lung cancer SIR (95% CI), not increased
- 4.17 (0.50-15.05)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| DM as independent risk factor for cancer in acromegalyDMvs No DM | 7.01 (1.23–39.99) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Cancer | No cancer | P value |
|---|---|---|---|
| Diagnostic delayProlonged in cancer group | 10.1 (range 8.6–14.3) | 3.8 (range 1.3–9.0) | P = 0.005 |
| Duration of acromegalyProlonged in cancer group | 12.8 (range 8.9–16.4) | 5.6 (range 2.3–10.9) | P = 0.008 |
Original publication
Cancer Risk and its Association With Diabetes Mellitus in Patients With Acromegaly: A Two Center-based Study. Endocr Pract. Published 19 June 2023. doi:10.
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