Characteristics and response cutoff of octreotide suppression test in thyrotrophin (TSH)‐secreting pituitary adenomas
Authors' conclusion
OST can be used as an efficient tool to guide the adequate use of SSA.
Study context
- Population
- Pathologically confirmed TSHoma patients with complete 72 h octreotide suppression test (OST) data
- Participants
- 48 participants
- Outcome
- Sensitivity timepoint and cutoff of OST
Performance
As reported in the abstract
- Optimal timepoint: 24th hour; cutoff: TSH decrease (50% of median value of TSH in 72-h OST)
- 44.54%
- 24-h timepoint most predictive of percentage TSH decline (both short- and long-acting SSA), Spearman r
- r = .571, p < .001
- 72-h timepoint optimal for predicting magnitude of TSH decline (both short- and long-acting SSA), Spearman r
- r = .438, p = .005
- Long-acting SSA: 72-h timepoint optimal for predicting percentage of TSH decline, Spearman r
- r = .587, p = .01
- Long-acting SSA: 72-h timepoint optimal for predicting magnitude of TSH decline, Spearman r
- r = .474, p = .047
Further findings
Maximal hormone decline during entire OST · 72 h
- TSH maximal decline
- 89.07% (73.85%, 96.77%)
- FT3 decline
- 43.40% (37.80%, 54.44%)
- FT4 decline
- 26.59% (19.01%, 33.13%)
Timepoint of stability
- Stability at 24th hour for TSH, 48th hour for FT3 and FT4
Correlation at 24 h of TSH suppression rate with FT3 and FT4 decrease
- Positive correlation between TSH suppression rate and percentage and absolute decrease of FT3 and FT4
Paradoxical response and hormonal control
- Paradoxical response could occur and did not influence SSA effect if sensitivity confirmed
- High level of hormonal control in SSA-sensitive patients
Safety
Adverse effects of OST
- Adverse effects predominantly gastrointestinal; no severe event
Original publication
Characteristics and response cutoff of octreotide suppression test in thyrotrophin (TSH)‐secreting pituitary adenomas. Clin Endocrinol (Oxf). Published 11 June 2023. doi:10.
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